[All] Estimating Burden & Disease Costs of Exposure to Endocrine-Disrupting Chemicals

[Carole Clinch]

Estimating Burden and Disease Costs of Exposure to Endocrine-Disrupting
Chemicals in the European Union
http://press.endocrine.org/doi/10.1210/jc.2014-4324
http://press.endocrine.org/doi/pdf/10.1210/jc.2014-4324

The EU has banned substances that we are still using/exporting in N. America

Context:

Rapidly increasing evidence has documented that endocrine-disrupting
chemicals (EDCs) contribute substantially to disease and disability.
 Objective:

The objective was to quantify a range of health and economic costs that can
be reasonably attributed to EDC exposures in the European Union (EU).
  Results:

Expert panels achieved consensus at least for probable (>20%) EDC causation
for IQ loss and associated intellectual disability, autism,
attention-deficit hyperactivity disorder, childhood obesity, adult obesity,
adult diabetes, cryptorchidism, male infertility, and mortality associated
with reduced testosterone. Accounting for probability of causation and
using the midpoint of each range for probability of causation, Monte Carlo
simulations produced a median cost of €157 billion (or $209 billion,
corresponding to 1.23% of EU gross domestic product) annually across 1000
simulations. Notably, using the lowest end of the probability range for
each relationship in the Monte Carlo simulations produced a median range of
€109 billion that differed modestly from base case probability inputs.
 Conclusions:

EDC exposures in the EU are likely to contribute substantially to disease
and dysfunction across the life course with costs in the hundreds of
billions of Euros per year. These estimates represent only those EDCs with
the highest probability of causation; a broader analysis would have
produced greater estimates of burden of disease and costs.
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